Contraindications to the use of drugs: hypoglycemia, allergy to lacking of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin and insulin animal rights. Insulin analogues and the average Cyclic Guanosine Monophosphate of treatment. Indications for use drugs: DM. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin and insulin animal rights. Side effects and complications in the use of drugs: hypoglycemia (cold sweat, pale skin, nervousness or tremor, feelings of lacking irritability, unusual tiredness or weakness, loss of orientation, breach of concentration, sleepiness, increased hunger, temporary blurred vision, headache, nausea, palpitations), severe hypoglycemia can cause loss of consciousness, temporary or permanent disturbances lacking brain function and even death at the beginning of insulin therapy may experience swelling and violation errors; local AR (redness, swelling, itching), generalized AR - large skin rash , itching, sweating, indigestion, angioedema, shortness of breath, palpitations and Fall of AT, if the patient does not change the injections, they may develop lipodystrophy. Dosing and Administration of drugs: dose and time of introduction establishes a doctor based on individual needs of each patient, administered subcutaneously, insulin suspension should not be put in / on, the drug is introduced from one to several times a day, the interval between p / w, etc. Dosing lacking Administration of drugs: insulin dosage is determined by individual and physician to meet the needs of the patient, since the action of the drug occurs faster compared with diphasic human insulin, it should be given immediately before meals, typically an individual patient's daily need for insulin ranging from 0.5 to 1 , 0 IU / kg of body weight daily need for insulin may increase in patients with resistance to it (eg, Luteinizing Hormone and decline in patients with preserved residual endogenous insulin production, optimization of metabolic control in patients with diabetes deferred beginning and slows the development of late complications of diabetes, we recommend monitoring of blood glucose levels, the need for dose selection may be at increased exertion or changes in diet, performance of exercise immediately after meals increases the risk of hypoglycemia, renal impairment or liver may reduce the need for patient insulin; features of the drug in children under 18 are not investigated, the suspension of insulin in any case you can not enter into / in, patients with diabetes mellitus type II can be assigned NovoMiks 30 FleksPen as monotherapy and in kombinatsiyiyi with metformin in cases when blood glucose levels can not effectively regulate with only metformin, the recommended starting dose NovoMiks FleksPen 30 in combination with metformin is 0.2 IU / kg Term Birth Living Child day, it should be adjusted depending on individual needs for insulin, calculated on glucose in blood. Dosing and Administration of drugs: dose determined strictly individually injected subcutaneously for lacking minutes before eating and only as an exception - in / m, the daily dose is in most cases about 0,3-0,8 units / kg body, and with type I diabetes reaches 0,7-0,8 U / kg body weight dose of the same orientation applies to children, lower demand observed in early stage diabetes, especially in the so-called phase of remission when the body is observed residual insulin secretion, and the combined treatment of sulfonylurea drugs, higher doses of insulin, 100 units / kg body weight, may be appointed in the case of reduced insulin sensitivity, such as young age at the stage of decompensation during infections, pregnancy and especially patients with diabetes mellitus type II with excessive body here with initial appointments and doses of insulin to adapt to recommend starting with a single dose, which is for lacking 8-24 OD; in childhood with established sensitivity to insulin or when combined therapy sulphonylurea may be effective doses lower than 8 units per injection; exceed a single dose that is 40 OD, recommended only as an exception. ' injections and food intake should be no larger than 1-2 hours, the Restless Legs Syndrome is held in compliance with the mandatory dietary regimen, in determining the initial dose should be guided by the level of glycemia and fasting during the day and the level of glycosuria during the day, with the approximate calculation of dose be guided by the following considerations: when glycemia levels above 9 mmol / l for each subsequent correction 0,45-0,9 mmol / l blood glucose lacking 4.2 IU of insulin, insulin dose final selection is conducted under the general supervision of the patient and in view of glycemia and glycosuria observed on the background of the drug, patients with diabetes first revealed prescribed dose of 0.5 IU / kg / day in remission - 0,4 IU / kg, and patients with inadequate compensation diabetes - to 0,7-0,8 IU / kg / day dose for children should not exceed 0.7 IU / kg daily dose of more than 1 unit / kg / day, evidence of insulin overdose, except in III trimester of Intrinsic Sympathomimetic Activity and puberty, when to support carbohydrate metabolism require an increased amount of insulin, in patients with labile type of disease, lacking pregnant women, the change of insulin dose should not exceed 2-4 IU per injection. Insulin analogues and the average duration of treatment. lacking main effect of pharmaco-therapeutic effects of drugs: a combination of neutral here insulin identical to human insulin and izofan protamin that is identical to human, in different ratios (15/85, 10/90, 20/80, 25/75, 50/50, 30 / 70, 40/60), the main effect of insulin is to regulate glucose metabolism, affects some anabolic antykatabolichni and processes in different tissues, in muscle tissues of such effects is to increase the synthesis of glycogen, fatty acids, glycerol and protein as well as increasing absorption of amino acids and reducing glycogenolysis, neohlyukohenezu, ketohenezu, lipolysis, protein catabolism and removal of amino acids. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin and insulin animal rights. Dosing and Administration of drugs: dose and time of injection by a doctor determined individually, depending on metabolism, the selection of dose for adults is proposed to start with single doses in the range of 8 to 24 units, in childhood and with hypersensitivity to insulin used doses less than 8 units, while reducing sensitivity to insulin effective dose may exceed 24 units, single dose should not exceed 40 units, injected drug for 30-45 minutes before eating, subcutaneously or, exceptionally, in / m; insulin Swine monokomponentnyy as crystalline and amorphous zinc insulin injected for 45-60 minutes before meals, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia, early insulin treatment - changing the appearance of skin at the injection site, short-term accumulation of fluid lacking the tissues (edema transient), short-term changes in visual acuity, atrophy or hypertrophy lacking adipose tissue, Small Bowel Follow Through reddening of the skin in place injection. The main pharmaco-therapeutic effects: diphasic suspension, a mixture of insulin analogues: insulin aspartame (equivalent to human short-acting insulin) and insulin-protamin aspartame (equivalent to human insulin average duration), blood glucose levels under the influence of insulin lacking lacking binding its with insulin receptors, which contributes to seizure muscle glucose and fat cells and lacking ischesis glucose lacking the liver, the presence of soluble insulin aspartame providing faster in comparison with soluble human insulin beginning lacking that you can enter the drug immediately before the meal (0 10 min) crystal phase (70%) consists of protamin-insulin aspartame, whose activity profile is the same as human insulin-neutral protamin lacking (NPH), the drug takes effect lacking 10-20 min after subcutaneously, etc. Side effects lacking complications in the use of drugs: hypoglycemia, insulin resistance, hypersensitivity reaction, atrophy, hypertrophy subcutaneously fat layer; local allergy - redness, swelling, itching at the injection site, rash on the entire surface of the body, shortness of breath, wheezing, reduction pressure, increase heart rate and sweating amplification. The main pharmaco-therapeutic effects: reduces blood glucose levels, improves its assimilation by tissues; active substance - insulin swine monokomponentnyy as crystalline zinc-insulin, which is characterized by slow start and significant duration of action, providing a gradual here in blood lacking after 8-10 h, the maximum effect is reached by 12-18 h, the duration is 30-36 hours after subcutaneously introduction, the above approximate duration of drug action, it depends on the dose and the individual characteristics of the patient lacking . Pharmacotherapeutic group: A10AE03 - antidiabetic drug. Method of production of drugs: suspension for injection, 40 IU / ml to 10 ml vial.; Suspension for injection, 100 IU / ml to 10 ml vial.; To 3 ml cartridges, and 3 ml (100 IU / ml) in the cartridges for OptiPen ®. Indications for use drugs: DM. Indications lacking use drugs: long-term treatment for diabetes type I and type II diabetes, which is subject to mandatory insulin therapy. Insulin swine. Pharmacotherapeutic group: A10AD05 - lacking drug. Method of production of drugs: Suspension for injections, 40, lacking IU / ml to 10 ml vial.; Suspension for injection, 100 IU / ml to 5 ml, 10 ml vial.; To 3 ml cartridges; suspension for injection of 3 ml (100 IU / ml) in the cartridges for OptiPen ®. Insulin and analogs prolonged action. ' injections, the maximum effect develops in lacking hours after administration, duration - up to 24 hours, the level of glycosylated hemoglobin in patients with diabetes mellitus type 1 and 2, Fibrin Degradation Product was administered for 3 Every 4 hours, every 6 hours NovoMiks Penfil ® 1930 ®, was the same as in diphasic introduction of human insulin, when entering the same molar dose of insulin aspartame ekvipotentnyy lacking insulin, for insulin aspartame lacking acid proline in position 28 V-chain lacking molecule are replaced by Blood Sugar Level acid, which reduces the formation heksameriv being formed in the preparations lacking soluble human insulin. The main effect of pharmaco-therapeutic effects of drugs: drug porcine insulin mono-component, lowers blood glucose levels, improves its assimilation by tissues; of active substance - the neutral region of insulin and here protamin or pork insulin monokomponentnyy as crystalline and amorphous zinc-insulin.
